Unraveling Inflammatory Pain: A Narrative Review of Molecular Pathways and Multidisciplinary Treatments

Background Inflammatory pain is a widespread global health concern arising from complex molecular pathways triggered by a consequence of tissue damage and immune activation. It significantly impacts quality of life and functional outcomes, necessitating a comprehensive understanding of underlying mechanisms and multidisciplinary approaches for effective management. Aim This review aims to provide an integrative synthesis of the molecular mechanisms underlying inflammatory pain and to critically examine contemporary multidisciplinary therapeutic approaches for its management. It also highlights the essential role of nursing within the framework of precision and presence‐based care. Methods A narrative review was conducted using electronic searches across major databases, including SCOPUS, Web of Science, CINAHL, IBSS, and PubMed, to identify relevant English‐language publications from 2020 to 2025. Additional manual searches were performed by screening relevant journals and the reference lists of selected studies. The search strategy incorporated combinations of keywords such as molecular mechanisms of pain, inflammatory pain, nursing, and nurse. Results Recent advances in molecular science highlight the critical role of inflammatory mediators and signaling pathways in the development and maintenance of inflammatory pain. Effective management requires multidisciplinary strategies integrating pharmacological interventions, including nonsteroidal anti‐inflammatory drugs (NSAIDs), corticosteroids, and biologic agents, with adjunctive approaches such as physiotherapy, electrostimulation, and psychosocial interventions. Within this framework, nurses play a pivotal role in translating molecular insights into clinical practice by delivering evidence‐based, patient‐centered, and holistic care. Conclusion Integrating molecular understanding with multidisciplinary clinical approaches enhances pain assessment accuracy, treatment effectiveness, and patient outcomes. Strengthening nursing competencies in molecular pain mechanisms is essential to support precision care and optimize the management of inflammatory pain.