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Experimental evidence shows the efficient synthesis of fluorinated heterocycles using TBAF and alkynoates, highlighting its potential in drug development.
The strategic incorporation of fluorine into heterocyclic scaffolds is pivotal for drug discovery. Herein, we report a TBAF-initiated annulation of α-trifluoromethyl alkenes with alkynoates to assemble functionalized 2-fluoro-4H-pyran frameworks. This is an exceptional case of the annulation with alkynoates, in that just extra 10 mol % fluoride is needed.
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Chen et al. (2026) studied this question.
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