Answers are grounded in this paper and cite their sources.
Assesses safety of high-dose ascorbic acid in individuals, indicating long-term tolerance is achievable.
Summary: The few literature references suggesting adverse effects of high doses ofascorbic acid are outnumbered by a large number of clinical studies in which noadverse effects have been observed. Up to 5 g ascorbic acid daily may be administeredsafely even over a long term. Favourable effects of even higher doses in man may justifytherapeutic trials in the range of 15 g daily which in our trials have proven safe duringtreatment of up to 2 years. Nevertheless, trials in the high dosage range mentionedshould always be closely supervised by a physician, being aware that exceptionalbehaviour can occur at any time, as exception proves the rule.
No takes yet. Share an insight, caveat, or question.
A Hanck (1982) studied this question.
Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context: