Why the study?
Does ascorbic acid prevent induced rhinovirus 44 infection in healthy adult male volunteers?
Population
21 healthy, susceptible adult male volunteers
Comparison
Ascorbic acid 1 g three times daily for 3 weeks vs Placebo for 3 weeks
Design
RCT, double-blind
Follow-up
3 weeks
Authors
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High-dose ascorbic acid shows no rhinovirus prophylaxis; confirms ineffectiveness and advises against routine preventive use in adults.
Does ascorbic acid prevent induced rhinovirus 44 infection in healthy adult male volunteers?
High-dose ascorbic acid does not prevent rhinovirus infection when administered prophylactically.
Schwartz et al. (1973) studied this question.
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