Key result
Salicylic acid hand cleansers reduce rhinovirus infection ~78% vs controls after experimental contamination.
Why the study?
Direct hand-to-hand contact is an important mechanism of rhinovirus transmission, and organic acids have in vitro antirhinoviral activity that may prevent infection when applied to hands.
Does the application of organic acids to hands prevent rhinovirus infection in volunteers exposed to the virus?
Population
Volunteers with hands experimentally contaminated with rhinovirus
Comparison
3.5% salicylic acid, 1% salicylic acid with 3.5% pyroglutamic acid, or 4% pyroglutamic acid vs control
Design
Experimental study with viral culture and infection assessment
Follow-up
Up to 3 hours after application
Authors
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Supports organic acid hand treatments to curb rhinovirus transmission; extends volunteer RCT evidence for persistent antiviral hygiene.
Does the application of organic acids to hands prevent rhinovirus infection in volunteers exposed to the virus?
Absolute Event Rate: 7% vs 32%
p-value: p=< 0.05
Organic acids such as salicylic acid and pyroglutamic acid applied to hands have persistent antirhinoviral activity and can reduce the transmission of rhinovirus infection.
Turner et al. (2004) studied Rhinovirus infection. Salicylic acid (SA) and pyroglutamic acid (PGA) vs. controls was evaluated on Rhinovirus infection (p=< 0.05). Application of salicylic acid hand cleansers significantly reduced the incidence of rhinovirus infection compared to controls (7% vs 32%, P<0.05) following experimental hand contamination.
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