What question did this study set out to answer?

This research investigates the role of complement receptor 1 (CR1) in driving immunosuppressive tumor-associated macrophage (TAM) dysfunction in hepatocellular carcinoma (HCC).

May 27, 2026Journal of Translational MedicineOpen Access

CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection

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This research investigates the role of complement receptor 1 (CR1) in driving immunosuppressive tumor-associated macrophage (TAM) dysfunction in hepatocellular carcinoma (HCC).
Utilized integrative genetic and multi-omics framework including Mendelian randomization and metabolite mediation analyses.
Analyzed data from TCGA-HCC cohort, single-cell RNA-sequencing of 53,474 cells, and spatial transcriptomic sections.
Conducted functional assays in macrophages with CR1 gain- and loss-of-function, including phagocytosis and T-cell co-culture experiments.
MR analyses indicated that CR1 is linked to HCC susceptibility (IVW OR = 1.403, p = 0.017).
CR1-high tumors displayed increased M2-like macrophages and decreased CD8 + T-cell infiltration, correlating with poorer survival outcomes.
Functional assays showed CR1 overexpression led to enhanced M2 polarization and suppressed CD8 + T-cell activity.

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Implication

Randomized trial uncovers CR1's role in promoting immunosuppressive conditions in hepatocellular carcinoma, suggesting new therapeutic strategies.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a168b160c924ddd1bd59f6e https://doi.org/10.1186/s12967-026-08301-z

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Implication

Randomized trial uncovers CR1's role in promoting immunosuppressive conditions in hepatocellular carcinoma, suggesting new therapeutic strategies.

CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection

Key Points

Discussion

Implication

Cite This Study

CR1(+) tumor-associated macrophages orchestrate an immunosuppressive niche in hepatocellular carcinoma: a genetic and multi-omics dissection

Key Points

Discussion

Implication

Cite This Study

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