Superoxide-Driven Oxi-Inflammatory Activation in PBMC Cultures: Evidence Supporting a Cellular Ageing Trigger

Ivana Beatrice Mânica da Cruz; Juliane Sasso; Marco Aurélio Echart Montano; Raquel de Souza Praia; da Cruz Jung Ivo Emílio; Maria Fernanda Mânica-Cattani; Cristina Maranghello; Railla da Silva Maia; Marcelo Araújo da Silva; Vitória Farina Azzolin; Vitória Farina Azzolin; Franciele Bugiareki; Eduardo Velez-Martin; Ednea Aguiar Maia‐Ribeiro; Euler Esteves Ribeiro; Verônica Farina Azzolin; Verônica Farina Azzolin

doi:10.1080/10715762.2026.2678398

May 25, 2026Free Radical Research

Superoxide-Driven Oxi-Inflammatory Activation in PBMC Cultures: Evidence Supporting a Cellular Ageing Trigger

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Key Points

This research aims to investigate how superoxide dysregulation initiates oxi-inflammatory activation in PBMCs and its relation to cellular ageing.
Cultured peripheral blood mononuclear cells (PBMCs) were assessed for oxi-inflammatory activation due to superoxide.
Analyses focused on the signalling pathways affected by superoxide dysregulation.
Findings indicate that superoxide dysregulation significantly triggers oxi-inflammatory responses in PBMCs.
The results support the hypothesis that this process plays a role in cellular ageing mechanisms.

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Implication

Shows superoxide dysregulation triggers oxi-inflammatory activation in PBMC cultures, suggesting a link to ageing.

Abstract

imbalance initiates oxi-inflammatory activation in PBMCs, supporting superoxide dysregulation as a potential CAT and a hormetic modulator of ageing-related signalling.

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Cite This Study

Cruz et al. (2026) studied this question.

synapsesocial.com/papers/6a168b280c924ddd1bd5a16b https://doi.org/10.1080/10715762.2026.2678398

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Superoxide-Driven Oxi-Inflammatory Activation in PBMC Cultures: Evidence Supporting a Cellular Ageing Trigger

Key Points

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Implication

Abstract

Discussion

Cite This Study

Superoxide-Driven Oxi-Inflammatory Activation in PBMC Cultures: Evidence Supporting a Cellular Ageing Trigger

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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