Bariatric surgery in women with obesity and HFpEF reduced MLHFQ scores (P<0.02), cardiac mass (P<0.001), and liver fat (P=0.007), and increased e' (P=0.03), without changing cardiac fat.
Cohort (n=34)
Does bariatric surgery improve cardiac function, symptoms, and myocardial lipid deposition in women with obesity and HFpEF?
Bariatric surgery in women with obesity and HFpEF improves symptoms, induces reverse cardiac remodeling, and improves diastolic relaxation, though these benefits do not appear to be driven by changes in myocardial fat deposition or plasma lipidomics.
OBJECTIVE: To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). METHODS: A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22). RESULTS: After surgery-induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P < 0.02, P < 0.001, and P = 0.007, respectively); echo-derived e' increased (P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate. CONCLUSIONS: Surgery-induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity-related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.
Mikhalkova et al. (Fri,) conducted a cohort in Obesity and heart failure with preserved ejection fraction (HFpEF) (n=34). Bariatric surgery (gastric bypass) vs. Baseline (pre-surgery) was evaluated on Myocardial lipid deposition, cardiac function, and plasma lipidome. Bariatric surgery in women with obesity and HFpEF reduced MLHFQ scores (P<0.02), cardiac mass (P<0.001), and liver fat (P=0.007), and increased e' (P=0.03), without changing cardiac fat.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: