Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study

Taylor D. Coston; Shelton W. Wright; Viriya Hantrakun; Kristina E. Rudd; Parinya Chamnan; Gumphol Wongsuvan; T. Eoin West; Direk Limmathurotsakul

doi:10.1097/ccm.0000000000006932

November 6, 2025Critical Care MedicineOpen Access

Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study

View Full Paper

Ask AI

Bookmark

Share

Key Points

To determine whether antibiotic administration prior to hospital referral improves 28-day survival in adults with sepsis, and whether this effect varies by the presence of septic shock.
Conducted a secondary analysis of a prospective cohort of 2,593 adults referred from community hospitals to a tertiary center in Thailand with sepsis defined by suspected infection and a modified Sequential Organ Failure Assessment score ≥ 2.
Used propensity score matching to compare outcomes among patients who received pre-referral antibiotics versus those who did not, stratified by shock status (n = 244 with septic shock; n = 722 without shock).
Septic shock significantly modified the effect of pre-referral antibiotic administration on 28-day survival (interaction p = 0.001).
Among patients with septic shock, pre-referral antibiotics were associated with a lower risk of death (HR, 0.38; 95% CI, 0.19–0.75).
Among patients with sepsis without shock, pre-referral antibiotics were not associated with a statistically significant difference in mortality (HR, 1.36; 95% CI, 0.96–1.92).

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Cohort study reveals pre-referral antibiotics decrease mortality in patients with septic shock, indicating urgent antimicrobial timing is most essential during circulatory collapse.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Coston et al. (2025) studied this question.

synapsesocial.com/papers/6a16974b77556771e2b25670 https://doi.org/10.1097/ccm.0000000000006932

View Full Paper

Ask AI

Bookmark

Share

Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Pre-Referral Antibiotics and Mortality Among Adults With Sepsis in Southeast Asia: A Secondary Analysis of a Prospective Cohort Study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading