Key result
Treatment with perindopril or spironolactone significantly suppressed osteopontin expression and partly prevented cardiac fibrosis and ventricular dysfunction in rats following myocardial infarction (P<0.01).
Why the study?
Does treatment with perindopril or spironolactone reduce osteopontin expression and cardiac remodeling in rats with myocardial infarction?
RCT (n=65)
Randomly divided
Does treatment with perindopril or spironolactone reduce osteopontin expression and cardiac remodeling in rats with myocardial infarction?
p-value: p=<0.01
Angiotensin and aldosterone blockades reduce osteopontin expression and attenuate cardiac remodeling and fibrosis in a rat model of myocardial infarction.
No takes yet. Share an insight, caveat, or question.
Should not alter post-MI therapy in humans; leaves open whether osteopontin suppression improves clinical outcomes.
Zhang et al. (2008) conducted an RCT in Myocardial infarction (n=65). Perindopril and Spironolactone vs. Saline and sham operation was evaluated on Osteopontin protein expression, interstitial fibrosis infiltration, and left ventricular function (p=<0.01). Treatment with perindopril or spironolactone significantly suppressed osteopontin expression and partly prevented cardiac fibrosis and ventricular dysfunction in rats following myocardial infarction (P<0.01).
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