Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I. Hypertrophy, hyperplasia, and binucleation of myocytes.

Q: What does this research mean for the field?

During early postnatal development in rats, the greater weight gain of the left ventricle compared to the right is primarily driven by a 61% greater proliferation of myocytes, resulting in a combination of eccentric and concentric hypertrophy in the left ventricle versus eccentric hypertrophy in the right. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Piero Anversa; G Olivetti; Alden V. Loud

doi:10.1161/01.res.46.4.495

April 1, 1980Circulation ResearchOpen Access

Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I. Hypertrophy, hyperplasia, and binucleation of myocytes.

View Full Paper

Ask AI

Bookmark

Share

Key Points

This study aims to analyze the growth dynamics of myocytes in the left and right ventricles during early postnatal development.
Observed myocyte populations morphometrically from 1 to 11 days post-birth.
Measured hypertrophy, hyperplasia, and binucleation in the left and right ventricular myocardium.
Analyzed changes in cell volume, length, and percentage of binucleated myocytes over time.
From 1 to 11 days, myocyte hypertrophy was observed at 2.7-fold in the left and 2.4-fold in the right ventricles.
Left ventricle showed 61% greater myocyte proliferation, contributing to a 2-fold difference in weight gains: 6.2-fold (L) vs. 3.4-fold (R).
The percentage of binucleated myocytes increased from 2.7% to 48% over 11 days, indicating significant myocyte maturation.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Postnatal myocyte growth patterns extend fetal workload observations; leaves open molecular drivers and clinical translation in developmental cardiology.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Anversa et al. (1980) studied this question.

synapsesocial.com/papers/6a169d272fcf950e0005100b https://doi.org/10.1161/01.res.46.4.495

View Full Paper

Ask AI

Bookmark

Share

Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I. Hypertrophy, hyperplasia, and binucleation of myocytes.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I. Hypertrophy, hyperplasia, and binucleation of myocytes.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading