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February 1, 1978Circulation ResearchOpen Access

The influence of aging and growth on the postnatal development of cardiac muscle in rats.

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Population

Newborn rats

Comparison

Altered postnatal body growth rates by adjusting… vs Normal growth rate (litter size of 8)

Design

Preclinical

Follow-up

21 days

Authors

KRK RakusanUniversity of OttawaSRSubha V. RamanCardiac ImagingRLRoss LayberryHarvard University

Discussion

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Implication

Supports growth velocity as a determinant of myocyte proliferation; hypothesis-generating and should not yet inform clinical practice.

Structured PICO

P
Population
Newborn rats
I
Intervention
Altered postnatal body growth rates by adjusting litter size to 4 (fast-growing) or 16 (slow-growing)
C
Comparator
Normal growth rate (litter size of 8)
O
Outcome
Left ventricular weight, myocyte diameter, and estimated total number and length of myocytessurrogate

Accelerated growth of the heart during the early postnatal period in rats is associated with increased proliferation of myocytes.

Cite This Study

Rakusan et al. (1978) studied this question.

synapsesocial.com/papers/6a8c2980eada60f85de3dc5dhttps://doi.org/10.1161/01.res.42.2.212
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitosis of Heart Muscle Cells in Normal Rats1968 · 52 citations
  2. 2Endocardial Fibroelastosis of Large Mammals1965 · 26 citations
  3. 3A determination of the diameters of ventricular myocardial fibers in man and other mammals1945 · 62 citations
  4. 4Some effects of accelerating growth - I. General somatic development1960 · 382 citations