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September 14, 2011Journal of Cellular and Molecular MedicineOpen Access

Epicardial epithelial-to-mesenchymal transition in injured heart

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Key result

Following myocardial infarction, reactivated epicardium in the infarcted region showed significant epithelial-to-mesenchymal transition, supporting its active involvement in repair and regeneration.

Population

Preclinical model with myocardial infarction using an inducible epicardial Cre line and a double…

Comparison

Myocardial infarction vs Remote (uninjured) epicardium

Design

Preclinical

Authors

BZBin ZhouWPWilliam T. Pu

Discussion

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Overview

Supports epicardial EMT in rodent post-MI repair; leaves open translation to human regenerative therapies.

Structured PICO

P
Population
Preclinical model with myocardial infarction using an inducible epicardial Cre line and a double fluorescence reporter
I
Intervention
Myocardial infarction
C
Comparator
Remote (uninjured) epicardium
O
Outcome
Epicardial epithelial-to-mesenchymal transition (EMT)surrogate

This study provides visual evidence that the epicardium actively participates in the repair and regeneration of infarcted myocardium through epithelial-to-mesenchymal transition.

Cite This Study

Zhou et al. (2011) studied Myocardial infarction. Cre-LoxP-mediated genetic lineage trace was evaluated on Epicardial epithelial-to-mesenchymal transition (EMT). Following myocardial infarction, reactivated epicardium in the infarcted region showed significant epithelial-to-mesenchymal transition, supporting its active involvement in repair and regeneration.

synapsesocial.com/papers/6a169ee62fcf950e000511b1https://doi.org/10.1111/j.1582-4934.2011.01450.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adult mouse epicardium modulates myocardial injury by secreting paracrine factors2011 · 525 citations
  2. 2Identification of Myocardial and Vascular Precursor Cells in Human and Mouse Epicardium2007 · 222 citations
  3. 3Cardiac renewing: interstitial Cajal‐like cells nurse cardiomyocyte progenitors in epicardial stem cell niches2009 · 135 citations
  4. 4Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis2010 · 150 citations
  5. 5Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections2011 · 128 citations