What question did this study set out to answer?

To determine the prevalence of gastro-oesophageal reflux symptoms and investigate underlying oesophageal motor dysfunction in adults with cystic fibrosis.

January 1, 1998Journal of the Royal Society of MedicineOpen Access

Prevalence and Mechanisms of Gastro-Oesophageal Reflux in Adult Cystic Fibrosis Patients

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To determine the prevalence of gastro-oesophageal reflux symptoms and investigate underlying oesophageal motor dysfunction in adults with cystic fibrosis.
Surveyed upper gastrointestinal symptoms using a structured questionnaire in 50 adult cystic fibrosis patients (mean age 26 years, range 16–50; 24 male).
Conducted oesophageal manometry and 24-hour pH monitoring in 10 symptomatic patients (mean age 28 years, range 21–35; 8 men).
Upper gastrointestinal symptoms occurred in 94% of patients (47/50), including heartburn in 80% (40/50), dyspepsia in 56% (28/50), and regurgitation in 52% (26/50).
Among the 10 monitored patients, 8 had elevated DeMeester scores indicating significant acid reflux, 6 had subnormal lower oesophageal sphincter barrier pressure, and 3 showed uncoordinated peristalsis.
Patients with a lower oesophageal sphincter barrier pressure < 5 mm Hg had significantly higher DeMeester scores (mean 81.0, range 47.9–128.8) than those with normal pressure (mean 26.9, range 8.7–56.5; p < 0.002).

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Implication

Observational study reveals high rates of acid reflux and impaired sphincter function in adults with cystic fibrosis, indicating significant gastrointestinal burden.

Cite This Study

Ledson et al. (1998) studied this question.

synapsesocial.com/papers/6a16a22e77556771e2b2623d https://doi.org/10.1177/014107689809100103

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Implication

Observational study reveals high rates of acid reflux and impaired sphincter function in adults with cystic fibrosis, indicating significant gastrointestinal burden.

Prevalence and Mechanisms of Gastro-Oesophageal Reflux in Adult Cystic Fibrosis Patients

Key Points

Discussion

Implication

Cite This Study

Prevalence and Mechanisms of Gastro-Oesophageal Reflux in Adult Cystic Fibrosis Patients

Key Points

Discussion

Implication

Cite This Study

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