What question did this study set out to answer?

To determine whether inhibiting gastric acid secretion with ranitidine alleviates asthma symptoms in pediatric and adolescent patients with or without pathological gastro-oesophageal reflux.

February 1, 1992European Respiratory JournalOpen Access

A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux

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Authors

PGPM GustafssonLinköping University NKN.‐I. M. KjellmanLinköping University LTLita TibblingLinköping University Hospital

Discussion

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Implication

Randomized double-blind trial reveals modest nocturnal asthma symptom reduction from ranitidine in youth with acid reflux, indicating reflux acts as a weak bronchoconstrictive trigger.

Key Points

To determine whether inhibiting gastric acid secretion with ranitidine alleviates asthma symptoms in pediatric and adolescent patients with or without pathological gastro-oesophageal reflux.
Conducted a double-blind, cross-over, placebo-controlled trial across four weeks in 37 children and adolescents (mean age 14 years) with bronchial asthma.
Stratified participants into a pathological gastro-oesophageal reflux (GOR) group (n=18) and a normal GOR control group (n=19) based on prior 24-hour esophageal pH monitoring.
Administered ranitidine as a single evening dose of 300 mg (150 mg if body weight was less than 40 kg) or placebo daily for four weeks.
Ranitidine produced a modest (30%) but statistically significant reduction in nocturnal asthma symptoms in patients with pathological GOR compared to controls with normal GOR.
Symptom improvement in asthma correlated significantly with the severity of acid reflux, while reported drug side-effects were negligible.

Cite This Study

Gustafsson et al. (1992) studied this question.

synapsesocial.com/papers/6a16a22e77556771e2b26240 https://doi.org/10.1183/09031936.93.05020201

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Implication

Randomized double-blind trial reveals modest nocturnal asthma symptom reduction from ranitidine in youth with acid reflux, indicating reflux acts as a weak bronchoconstrictive trigger.

A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux

Discussion

Member takes

Implication

Key Points

Cite This Study

A trial of ranitidine in asthmatic children and adolescents with or without pathological gastro-oesophageal reflux

Discussion

Member takes

Implication

Key Points

Cite This Study

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