Key result
Perivascular adipose tissue secretes chemokines like IL-8 and MCP-1 that induce leukocyte chemotaxis, suggesting it contributes to the progression of obesity-associated atherosclerosis.
Observational
Perivascular adipose tissue secretes chemokines that promote leukocyte migration, suggesting a mechanism linking obesity to atherosclerosis progression.
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May link perivascular adipose tissue to obesity-related atherosclerosis; hypothesis-generating in animals and requires human validation before clinical consideration.
Henrichot et al. (2005) conducted an observational in Obesity-associated atherosclerosis. Perivascular adipose tissue (pWAT) was evaluated on Chemotaxis of peripheral blood leukocytes and chemokine production. Perivascular adipose tissue secretes chemokines like IL-8 and MCP-1 that induce leukocyte chemotaxis, suggesting it contributes to the progression of obesity-associated atherosclerosis.
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