Why the study?
Does suprathreshold stimulation increase contractile strength via the release of an adrenergic mediator in isolated cardiac muscle?
Does suprathreshold stimulation increase contractile strength via the release of an adrenergic mediator in isolated cardiac muscle?
Suprathreshold stimulation increases contractile strength in isolated cardiac muscle via the release of norepinephrine.
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Norepinephrine release mediates suprathreshold effects in isolated muscle; leaves open frequency-dependent mechanisms and in vivo relevance.
Pharmacological evidence is presented supporting the theory that the increase in contractile strength of isolated cardiac muscle under suprathreshold stimulation is due to the release of an adrenergic mediator (norepinephrine). However, release of this material does not account for changes in contractile strength associated with changes in frequency of stimulation at threshold levels.
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Furchgott et al. (1959) studied this question.
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