A DNA aptamer structure is the basis of a molecular machine that can be instructed to grab or release the human blood-clotting factor α-thrombin, depending on the operator DNA sequence addressing it. In the picture the aptamer structure, which assumes a conformation characterized by two stacked guanine quadruplex structures, is linked to thrombin (gray ellipse).
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Dittmer et al. (2004) studied this question.
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