March 1, 1985Circulation Research

Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle.

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Population

Canine left ventricle model

Comparison

Acute ischemia vs Control (pre-ischemia state)

Design

Preclinical

Authors

WLWilbur Y.W. LewVeterans Medical Research Foundation of San Diego ZCZhongxiang ChenSouthwest University of Science and Technology BGBrian D. GuthBoehringer Ingelheim (Germany)

Discussion

Member takes

Implication

Questions reliance on nonischemic compensatory shortening to preserve ejection during acute ischemia; leaves open translation to clinical settings.

Structured PICO

Population

Canine left ventricle model

Intervention

Acute ischemia

Comparator

Control (pre-ischemia state)

Outcome

Segment shortening in nonischemic areas (isovolumic and ejection shortening)surrogate

During acute ischemia, apparent hyperfunction of nonischemic areas is expended in stretching the ischemic zone rather than providing compensatory ejection shortening.

Cite This Study

Lew et al. (1985) studied this question.

synapsesocial.com/papers/6a16ac65798df06fa4b268d3 https://doi.org/10.1161/01.res.56.3.351

View Full Paper

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Implication

Questions reliance on nonischemic compensatory shortening to preserve ejection during acute ischemia; leaves open translation to clinical settings.

Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of augmented segment shortening in nonischemic areas during acute ischemia of the canine left ventricle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider