Key result
AGT and AT1R genotype distributions were significantly different in essential hypertensive patients with left ventricular hypertrophy compared to healthy controls (p<0.05).
Why the study?
Are genetic polymorphisms in AGT and AT1R genes associated with the development of left ventricular hypertrophy in essential hypertensive patients?
Case-Control (n=190)
Are genetic polymorphisms in AGT and AT1R genes associated with the development of left ventricular hypertrophy in essential hypertensive patients?
p-value: p=<0.05
Mutations in the AGT and AT1R genes of the renin-angiotensin system are associated with the development of left ventricular hypertrophy in patients with essential hypertension.
AGT/AT1R variants may associate with LVH in hypertension; leaves open causal role and utility for genetic risk stratification.
Left ventricular hypertrophy in patients with hypertension is a main clinical prognostic entity The aim of this study was to evaluate the association between mutations at genes of the renin-angiotensin system (RAS) and the development of left ventricular hypertrophy. Genetic polymorphism in angiotensinogen (AGT) and angiotensin Il-type 1 receptor (AT1R) genes was examined in a group of well-selected essential hypertensive caucasians with left ventricular involvement (n = 40) and a group of healthy unrelated caucasians (n = 150). Cardiac morphology and function were assessed by M-mode echocardiography. Molecular variants were analysed by amplified fragment length polymorphism. We observed a statistically significant difference both for AGT and AT1R genotype distribution in patients with left ventricular hypertrophy compared with controls (p<0.05). A 0.49 and 0.225 frequency was detected among cases for T and C mutant alleles at AGT and AT1R genes. Mutations in RAS genes are involved in the pathophysiology of target-organ damage in essential hypertension. Evaluation of molecular factors conferring a risk of developing heart involvement may lead to better identification of patient subgroups and more effective control of the clinical course.
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Mettimano et al. (2002) conducted a case-control in Hypertensive heart disease with left ventricular hypertrophy (n=190). AGT and AT1R gene polymorphism vs. Healthy controls was evaluated on AGT and AT1R genotype distribution (p=<0.05). AGT and AT1R genotype distributions were significantly different in essential hypertensive patients with left ventricular hypertrophy compared to healthy controls (p<0.05).
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