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October 11, 2025PathogensOpen Access

Molecular Transmission Network and Pretreatment Drug Resistance of Newly Diagnosed HIV-1 Infections in Taizhou, a Coastal City in Eastern China, from 2021–2023

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Authors

JLJunxiao LinHLHaijiang LinGLGuixia Li

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Overview

Molecular epidemiological study reveals distinct transmission networks and drug resistance in newly diagnosed HIV-1 cases, highlighting rapid viral dissemination among older adults.

Key Points

  • To evaluate molecular transmission networks, subtype diversity, and pretreatment drug resistance patterns among newly diagnosed, treatment-naïve individuals with HIV-1.
  • Collected 1,126 plasma samples from newly diagnosed individuals between 2021 and 2023.
  • Amplified and sequenced the HIV-1 pol gene (n=937 successfully sequenced) to construct maximum likelihood phylogenetic trees and molecular transmission networks.
  • Identified pretreatment drug resistance (PDR) mutations via the Stanford University HIV Resistance Database and analyzed factors associated with large transmission clusters (≥10 members).
  • Characterized predominant circulating recombinant forms as CRF07_BC (42.1%, 395/937), CRF01_AE (27.6%, 259/937), and CRF08_BC (22.1%, 209/937).
  • Detected pretreatment drug resistance mutations in 11.4% (107/937) of successfully sequenced treatment-naïve individuals.
  • Identified age ≥60 years and the absence of PDR mutations as independent factors significantly associated with large transmission clusters of ≥10 individuals (p < 0.05).

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/6a16b02fc23c548e2a7b77b9https://doi.org/10.3390/pathogens14101030
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