Key result
A criticized preprint study estimated post-vaccination myocarditis rates of 162.2 per million in boys aged 12-15, exceeding the expected 44 per million risk of COVID-19 hospital admission.
Why the study?
Does the second dose of the Pfizer-BioNTech vaccine increase the risk of myocarditis compared to the risk of COVID-19 hospital admission in healthy adolescents?
Does the second dose of the Pfizer-BioNTech vaccine increase the risk of myocarditis compared to the risk of COVID-19 hospital admission in healthy adolescents?
Answers are grounded in this paper and cite their sources.
A preprint study claimed the risk of myocarditis after the second Pfizer-BioNTech vaccine dose in healthy boys exceeds the risk of COVID-19 hospitalization, but critics argue the study is deeply flawed due to inappropriate data mining.
Covid-19: Study that claimed boys are at increased risk of myocarditis after vaccination is deeply flawed, say critics Clara MunroThe risk of 12-15 year old healthy boys experiencing cardiac adverse events such as myocarditis after their second dose of the Pfizer and BioNTech vaccine is around four times adolescents' risk of being admitted to hospital as a result of infection with SARS-CoV-2, a preprint study has found. 1 However, the study has been widely criticised for mining data from an inappropriate source to deliver an antivaccine message, despite warnings against such data uses.The retrospective study, which has not yet been peer reviewed, used the US vaccine adverse reporting system (VAERS) to identify the rate of post-vaccination myocarditis among 12-15 and 16-17 year olds between January and June 2021 after the second dose of the Pfizer-BioNTech vaccine.The researchers concluded that the rate of cardiac adverse events after the second dose exceeded the expected rate of 120 day covid-19 hospital admission at both a moderate (August 2021) and a high (January 2021) incidence of SARS-CoV-2 infection.They estimated that the rate of cardiac myocarditis after the second dose of the vaccine was 162.2 cases per million in healthy boys aged 12-15 years and 94.0 per million in those aged 16-17.For girls the rate was 13 per million in 12-15 year olds and 13.4 per million in 16-17 year olds.Nearly all (86%) of the boys affected needed some form of hospital care, the authors said.By comparison, at current infection rates the risk of a healthy adolescent being admitted to hospital within 120 days of infection in the US is estimated to be 44 per million.
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Clara Munro (2021) conducted an editorial in Myocarditis after Covid-19 vaccination. Pfizer-BioNTech vaccine vs. Expected rate of 120-day covid-19 hospital admission was evaluated on Rate of cardiac adverse events/myocarditis. A criticized preprint study estimated post-vaccination myocarditis rates of 162.2 per million in boys aged 12-15, exceeding the expected 44 per million risk of COVID-19 hospital admission.
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