Key result
Endurance and resistance training show no difference in ventilatory chemoreflex sensitivities compared to untrained individuals.
Why the study?
Heightened chemoreflex sensitivity is associated with poor outcomes and therapeutic approaches are lacking, with unclear effects of endurance and resistance exercise training on ventilatory chemoreflex sensitivity.
Does endurance or resistance exercise training improve central and peripheral chemoreflex sensitivity in young healthy individuals compared to an untrained state?
Cross-Sectional (n=34)
No
Does endurance or resistance exercise training improve central and peripheral chemoreflex sensitivity in young healthy individuals compared to an untrained state?
In young healthy individuals, neither endurance nor resistance exercise training is associated with differences in central or peripheral ventilatory chemoreflex sensitivities compared to an untrained state.
Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10% O 2 , 5-minutes) and hyperoxic hypercapnic rebreathing (5% CO 2 -95% O 2 ) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇ E ) and end-tidal partial pressure of CO 2 . Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇ E from baseline to peak V̇ E expressed relative to the fall in oxygen saturation. Neither central (P=0.093) nor peripheral (P=0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations. • Heightened chemoreflex sensitivity is associated with poor outcomes • Exercise training improves central and peripheral chemoreflex sensitivity in animals • Central chemoreflex (hypercapnia) responses were not different in young humans • Peripheral chemoreflex (hypoxia) responses were also not different in young humans
No takes yet. Share an insight, caveat, or question.
Babbage et al. (2025) conducted a cross-sectional in Healthy (n=34). Endurance and resistance exercise training vs. Untrained was evaluated on Central ventilatory chemoreflex sensitivity (p=0.093). Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between endurance-trained, resistance-trained, and untrained young healthy individuals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: