Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 20, 2023Frontiers in EndocrinologyOpen Access

Integrated lipids biomarker of the prediabetes and type 2 diabetes mellitus Chinese patients

View Full Paper
Ask AI
Bookmark
Share

Key result

Integrated lipid biomarker signature effectively diagnoses prediabetes and T2DM with ~0.89 peak AUC.

  • n=533

Why the study?

Analyses of lipid metabolic profiles in T2DM have the potential to permit development of an integrated lipid metabolite-based biomarker model facilitating early diagnosis and treatment.

Can an integrated serum lipidomic biomarker signature accurately identify Chinese patients with newly diagnosed prediabetes and T2DM?

Population

93 discovery cohort and 440 validation cohort newly diagnosed Chinese participants

Design

Untargeted and targeted lipidomics biomarker discovery and validation study

Authors

JYJiaying YangShanghai Chest HospitalMWMei WangXi'an University of Science and TechnologyYDYang DaweiAffiliated Hospital of Youjiang Medical University for Nationalities

Discussion

Loading...

Member takes

Implication

May support lipidomic screening for prediabetes in Chinese adults; leaves open prospective validation and broader applicability.

Study Design

Type

Observational (n=533)

Multicenter

Yes

Structured PICO

Can an integrated serum lipidomic biomarker signature accurately identify Chinese patients with newly diagnosed prediabetes and T2DM?

P
Population
533 Chinese adults (aged 20-70 years) with newly diagnosed prediabetes or type 2 diabetes mellitus (T2DM) and healthy controls, divided into a discovery cohort (n=93) and a validation cohort (n=440). The study also included 30 rats (10 T2DM Goto-Kakizaki, 10 prediabetic Goto-Kakizaki, and 10 control Wistar).
C
Comparator
Healthy control participants with normal glucose tolerance
O
Outcome
Development of an integrated lipid metabolite-based biomarker signature for prediabetes and T2DM diagnosis (measured by Area Under the Curve [AUC])surrogate

A novel 8-lipid biomarker signature accurately identifies newly diagnosed prediabetes and T2DM in Chinese patients, highlighting the role of sphingomyelinase-regulated ceramide homeostasis in diabetes pathogenesis.

Limitations

  • The limited number of samples in the discovery cohort may have yielded false-negative results.
  • Whether glucose supplementation can effectively modulate sphingolipid metabolism within b cells by enhancing ceramide to SM conversion remains to be confirmed.

Cite This Study

Yang et al. (2023) conducted an observational in Prediabetes and Type 2 Diabetes Mellitus (n=533). Integrated lipids biomarker signature vs. Healthy controls was evaluated on Diagnostic accuracy (AUC) of integrated biomarker signature for T2DM. An integrated lipid biomarker signature effectively diagnosed prediabetes and type 2 diabetes mellitus with area under the curve values of 0.841 and 0.894, respectively.

synapsesocial.com/papers/6a16b57a87c007abbc051dd0https://doi.org/10.3389/fendo.2022.1065665

Topics

Lipid management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes2013 · 317 citations
  2. 2Inhibition of neutral sphingomyelinases in skeletal muscle attenuates fatty-acid induced defects in metabolism and stress2014 · 18 citations
  3. 3Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies2019 · 150 citations
  4. 4Altered Adipose and Plasma Sphingolipid Metabolism in Obesity2006 · 286 citations
  5. 5Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management2011 · 1,243 citations