Key result
Ultrafast ultrasound imaging revealed no significant differences in carotid stiffness and flow parameters between patients with bicuspid aortic valve and healthy first-degree relatives.
Why the study?
To compare carotid stiffness and flow parameters measured by ultrafast ultrasound imaging between bicuspid aortic valve patients and first-degree relatives.
Does bicuspid aortic valve alter carotid stiffness and flow parameters compared to healthy first-degree relatives?
Cross-Sectional (n=140)
No
Does bicuspid aortic valve alter carotid stiffness and flow parameters compared to healthy first-degree relatives?
Ultrafast ultrasound imaging demonstrates that carotid stiffness and flow parameters are not altered in patients with bicuspid aortic valve compared to healthy relatives, suggesting vascular remodeling in BAV is localized to the ascending aorta.
Carotid parameters appear unaffected in BAV; hypothesis-generating for localized aortic remodeling and requires prospective validation.
AIMS: To compare the carotid stiffness and flow parameters by ultrafast ultrasound imaging (UF), in bicuspid aortic valve (BAV) patients to first-degree relatives (controls). METHODS: = 48) were consecutively included at a reference center for BAV. Aortic valve and ascending aorta were evaluated by echocardiography. Common carotid arteries were evaluated by UF with a linear probe. A high frame rate (2,000 frames/s) was used to measure the pulse wave velocity (PWV). The arterial diameter change over the cardiac cycle was obtained by UF-Doppler imaging. This allowed us to measure the distensibility and the maximal rate of systolic distension (MRSD). The wall shear stress (WSS) was measured based on the same acquisitions, by analyzing blood flow velocities close to the carotid walls. RESULTS: < 0.001) at the Valsalva sinus and at the tubular ascending aorta but no larger carotid diameters. No significant differences were found in carotid stiffness parameters (distensibility, MRSD, and PWV), even though these patients had a higher aortic stiffness. Carotid stiffness correlated linearly with age and similar slopes were obtained for BAV patients and controls. No difference in carotid WSS was found between BAV patients and controls. CONCLUSION: Our results clearly show that the carotid stiffness and flow parameters are not altered in case of BAV compared with controls.
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Goudot et al. (2019) conducted a cross-sectional in Bicuspid Aortic Valve (n=140). Bicuspid aortic valve vs. Healthy first-degree relatives (tricuspid aortic valve) was evaluated on Carotid pulse wave velocity (PWV-1) (p=0.188). Ultrafast ultrasound imaging revealed no significant differences in carotid stiffness and flow parameters between patients with bicuspid aortic valve and healthy first-degree relatives.
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