Key result
Patients after aortic coarctation repair and those with bicuspid aortic valve had significantly higher central arterial stiffness (AP 7.86 and 7.68 vs 1.41 mmHg) compared to healthy controls.
Why the study?
Coarctation of the aorta is commonly related to bicuspid aortic valve, but arterial stiffness and the impact of concomitant bicuspid aortic valve after repair required evaluation.
Observational (n=118)
Absolute Event Rate: 7.86% vs 1.41%
p-value: p=<0.001
Adults who have undergone coarctation of the aorta repair and those with bicuspid aortic valves exhibit increased central arterial stiffness compared to healthy controls, though concomitance of both conditions does not further augment stiffness.
Objectives: The coarctation of aorta is commonly related to bicuspid aortic valve. The aim of the study was to assess arterial stiffness in adults after aortic coarctation repair and to evaluate an impact of bicuspid aortic valve concomitance on arterial stiffness results.Methods: Fifty-eight patients after coarctation of aorta repair, 36 male, median age of 27.46 ± 10.57, were compared to 30 with bicuspid aortic valve and to 30 healthy, sex, age and BMI matched volunteers. Physical examination, laboratory analysis and non-invasive assessment of arterial stiffness were performed.Results: CoA patients and BAV patients have higher central arterial stiffness parameters in comparison to healthy controls: AP (7.86 ± 6.56 vs 7.68 ± 5.96 vs 1.41 ± 3.82 mmHg, p < 0.001, p = 0.011, respectively) and AIx (18.81 ± 14.94 vs 18.06 ± 13.38 vs 4.41 ± 10.82%, p < 0.001, p = 0.006, respectively). There were no differences of PWV between CoA patients, BAV patients and healthy controls (6.07 ± 1.20 vs 5.95 ± 1.20 vs 5.67 ± 0.73 m/s, p = 0.099, p = 0.278, respectively). In CoA group, there was correlation of PWV with age (r = 0.55 p < 0.001), BMI (r = 0.29, p = 0.025), fibrinogen (r = 0.31, p = 0.039), glucose (r = 0.58, p < 0.001), ascending aorta diameter (r = 0.29, p = 0.026) and age at operation (r = 0.27, p = 0.041). Among group of BAV, there was a correlation of PWV with age (r = 0.58, p < 0.001), central AP with total cholesterol (r = 0.38, p = 0.036) and fibrinogen (r = 0.41, p = 0.024).Conclusions: The increased arterial stiffness occurs in both groups: patients after aortic coarctation repair and patients with bicuspid aortic valve. Concomitance of coarctation of the aorta and bicuspid aortic valve has no influence on arterial stiffness augmentation.
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Róg et al. (2018) conducted an observational in Coarctation of aorta and bicuspid aortic valve (n=118). Coarctation of aorta repair and/or bicuspid aortic valve vs. Healthy volunteers was evaluated on Central arterial stiffness parameter AP (mmHg) (p=<0.001). Patients after aortic coarctation repair and those with bicuspid aortic valve had significantly higher central arterial stiffness (AP 7.86 and 7.68 vs 1.41 mmHg) compared to healthy controls.
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