Key result
Patients with successfully repaired aortic coarctation exhibited significantly increased aortic arch pulse wave velocity (4.6 vs 3.5 m/s) and reduced thoracic aortic distensibility compared to healthy controls.
Why the study?
Do patients with successful early repair of aortic coarctation have abnormal aortic elasticity and left ventricular function compared to healthy controls?
Population
51 patients evaluated 13.9 ± 7.5 years after successful aortic coarctation repair, and 54 controls.
Comparison
Cardiovascular magnetic resonance (CMR) imaging vs Healthy controls
Design
Cross-sectional
Authors
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Impaired aortic elasticity post-CoA repair signals diastolic dysfunction; leaves open whether earlier repair or stiffness modulation improves long-term outcomes.
Cross-Sectional (n=105)
No
Do patients with successful early repair of aortic coarctation have abnormal aortic elasticity and left ventricular function compared to healthy controls?
Absolute Event Rate: 4.6% vs 3.5%
p-value: p=<0.01
Patients with successful early repair of aortic coarctation still exhibit impaired thoracic aortic elasticity and systemic vessel wall changes, which impact left ventricular diastolic function.
Voges et al. (2016) conducted a cross-sectional in Aortic coarctation (n=105). History of aortic coarctation repair vs. Healthy age-matched controls was evaluated on Pulse wave velocity in the aortic arch (m/s) (p=<0.01). Patients with successfully repaired aortic coarctation exhibited significantly increased aortic arch pulse wave velocity (4.6 vs 3.5 m/s) and reduced thoracic aortic distensibility compared to healthy controls.