Key result
Children with surgically repaired aortic coarctation exhibited a significantly higher stiffness index of the abdominal aorta compared to healthy controls (mean 0.625 vs 0.11, p=0.007).
Why the study?
The study evaluated arterial functions, including carotid intima-media thickness, flow-mediated dilatation, and aortic distensibility and stiffness, as early indicators of cardiovascular risk in children followed up after coarctation repair.
Does successful surgical repair of aortic coarctation prevent long-term vascular wall changes and arterial dysfunction in children compared to healthy controls?
Case-Control (n=47)
Does successful surgical repair of aortic coarctation prevent long-term vascular wall changes and arterial dysfunction in children compared to healthy controls?
Absolute Event Rate: 0.625% vs 0.11%
p-value: p=0.007
Children and adolescents exhibit detectable vascular wall changes and endothelial dysfunction even after successful aortic coarctation repair, indicating a potential risk for premature atherosclerosis.
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Higher aortic stiffness after coarctation repair signals residual vascular risk in children; extends evidence for early cardiovascular monitoring.
Çetiner et al. (2022) conducted a case-control in Surgically repaired aortic coarctation (n=47). Surgically repaired aortic coarctation vs. Healthy children was evaluated on Stiffness index of the abdominal aorta (p=0.007). Children with surgically repaired aortic coarctation exhibited a significantly higher stiffness index of the abdominal aorta compared to healthy controls (mean 0.625 vs 0.11, p=0.007).
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