Key result
Young adults following coarctation repair had reduced aortic distensibility and higher central aortic systolic blood pressure (P=0.04) compared to controls.
Why the study?
Patients with repaired aortic coarctation face high rates of cardiovascular and cerebrovascular disease related to hypertension, but the underlying mechanisms remain unclear.
Does prior coarctation repair alter aortic and carotid arterial biomechanics and central aortic systolic pressure in young adults compared to controls?
Cross-Sectional (n=85)
Does prior coarctation repair alter aortic and carotid arterial biomechanics and central aortic systolic pressure in young adults compared to controls?
p-value: p=0.04
Reduced aortic distensibility after coarctation repair is associated with greater transmission of aortic forward wave energy into the carotid artery and higher central aortic systolic blood pressure, potentially contributing to long-term cardiovascular and cerebrovascular risk.
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May signal heightened long-term CV and cerebrovascular risk post-repair; leaves open need for prospective outcome studies.
Kowalski et al. (2019) conducted a cross-sectional in Repaired aortic coarctation (n=85). Repaired aortic coarctation vs. Controls was evaluated on Brachial and central systolic blood pressure (p=0.04). Young adults following coarctation repair had reduced aortic distensibility and higher central aortic systolic blood pressure (P=0.04) compared to controls.
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