The increase in prevalence of comorbid medical and psychiatric disorders requiring combination pharmacotherapy has emphasized the need to better understand potential drug interactions with methadone. Because methadone is metabolized by the hepatic cyto-chrome P450 enzyme system, drugs that interact with that enzyme system, particularly the 3A4 family, have the potential of drug interactions with methadone. This paper reviews the literature of documented methadone drug interactions citing for each drug, the nature of the interaction, and the literature reference.
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Peter A. DeMaria (2003) studied this question.
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