Key result
Single-pill fixed-dose combinations improved the rates of systolic and diastolic blood pressure normalization by approximately 30% compared with the same medications given as a free-drug combination.
Why the study?
Do single-pill fixed-dose combinations improve medication adherence and blood pressure control in patients with hypertension compared to free-drug combinations?
Do single-pill fixed-dose combinations improve medication adherence and blood pressure control in patients with hypertension compared to free-drug combinations?
Effect estimate: OR 1.30 (95% CI 0.98-1.71)
Single-pill fixed-dose combinations, particularly ARB-based platforms, are recommended to reduce pill burden, improve patient adherence, and achieve better blood pressure control in hypertensive patients.
May support single-pill combinations for BP control; leaves open randomized confirmation of adherence benefits.
The satellite symposium was held in two separate sessions – the first a traditional symposium format, and the second as an interactive panel discussion in which the faculty answered questions from the delegates. The symposium objectives included consideration of the impact of suboptimal blood pressure (BP) control on the high levels of cardiovascular (CV) events in Europe; evaluation of the importance of patient adherence in improving management of BP; consideration of the management of treatment-resistant patients; discussion of a new initiative to drive improved management of hypertension; and how angiotensin receptor blocker (ARB)-based treatments and single-pill combinations may be used to treat hypertensive patients. Professor Burnier discussed the difficulties associated with achieving good BP control in the primary care setting and highlighted the utility of single-pill fixed-dose combinations (FDCs) for improving adherence and BP normalisation. Professor Ruilope discussed the clinical work-up and management of patients with treatment-resistant hypertension, while Professors Schmieder and Weiss outlined some initiatives taking place that aim to improve BP control rates. Finally, Professor Volpe described an ARB-based treatment platform which shows how patients can be effectively treated with single-pill combination therapy.
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Lynda McEvoy (2015) conducted a review in Hypertension. Single-pill fixed-dose combinations vs. Free-drug combinations was evaluated on Systolic and diastolic blood pressure normalization (OR 1.30, 95% CI 0.98-1.71). Single-pill fixed-dose combinations improved the rates of systolic and diastolic blood pressure normalization by approximately 30% compared with the same medications given as a free-drug combination.
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