Key result
The high-expression SERT genotype (LALA) was associated with a lower risk of ischemic stroke or TIA compared to combined low and medium expression genotypes (OR 0.73; 95% CI 0.58-0.93).
Why the study?
Does the high expression SERT genotype (LALA) reduce the risk of ischemic stroke/TIA compared to lower expression genotypes?
Case-Control (n=1,405)
No
Does the high expression SERT genotype (LALA) reduce the risk of ischemic stroke/TIA compared to lower expression genotypes?
Effect estimate: OR 0.73 (95% CI 0.58-0.93)
The high expression SERT genotype (LALA) is associated with a reduced risk of ischemic stroke or TIA, suggesting a potential genetic marker for stroke risk.
Does not alter stroke risk assessment; leaves open whether high-expression SERT genotype is protective pending prospective validation.
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Mortensen et al. (2018) conducted a case-control in Ischemic stroke/TIA (n=1,405). High-expression SERT genotype (LALA) vs. Low and medium expression SERT genotypes was evaluated on Risk of ischemic stroke/TIA (OR 0.73, 95% CI 0.58-0.93). The high-expression SERT genotype (LALA) was associated with a lower risk of ischemic stroke or TIA compared to combined low and medium expression genotypes (OR 0.73; 95% CI 0.58-0.93).
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