What question did this study set out to answer?

To comprehensively review the molecular characterization, regulation, physiological role, and clinical relevance of the sodium/iodide symporter in normal physiology and oncology.

February 1, 2003Endocrine ReviewsOpen Access

The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance

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Authors

ODOrsolya DohánSemmelweis University AVAntonio De la ViejaInstituto de Salud Carlos III VPViktoriya ParoderMemorial Sloan Kettering Cancer Center

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Implication

Scientific review demonstrates the molecular mechanisms and oncological utility of the sodium/iodide symporter, highlighting potential applications for radioiodide therapy in breast cancer.

Key Points

To comprehensively review the molecular characterization, regulation, physiological role, and clinical relevance of the sodium/iodide symporter in normal physiology and oncology.
Evaluated molecular and topological characteristics following rat and human NIS cDNA cloning and genomic sequencing.
Synthesized functional and electrophysiological analyses of basolateral membrane iodide translocation and tissue-specific regulation.
Assessed clinical applications, including congenital defect mutations, thyroid carcinoma ablation, and immunohistochemical screening in breast cancer specimens.
NIS mediates active, vectorial iodide uptake into the basolateral membrane of thyroid follicular cells and extra-thyroidal tissues like salivary and lactating mammary glands.
Over 80% of human breast cancer samples express endogenous NIS, presenting a target for radioiodide diagnostics and ablation.
Exogenous transduction of NIS cDNA successfully sensitizes non-thyroidal tumor cells to radioiodide-mediated destruction.

Cite This Study

Dohán et al. (2003) studied this question.

synapsesocial.com/papers/6a16c44b87c007abbc052808 https://doi.org/10.1210/er.2001-0029

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Implication

Scientific review demonstrates the molecular mechanisms and oncological utility of the sodium/iodide symporter, highlighting potential applications for radioiodide therapy in breast cancer.

The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance

Discussion

Member takes

Implication

Key Points

Cite This Study

The Sodium/Iodide Symporter (NIS): Characterization, Regulation, and Medical Significance

Discussion

Member takes

Implication

Key Points

Cite This Study

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