What question did this study set out to answer?

To evaluate long-term overall survival, disease-free survival, and patterns of treatment failure in patients with stage I or II follicular lymphoma.

May 1, 1995CancerOpen Access

Long term assessment of patterns of treatment failure and survival in patients with stage I or II follicular lymphoma

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To evaluate long-term overall survival, disease-free survival, and patterns of treatment failure in patients with stage I or II follicular lymphoma.
Retrospective cohort analysis of 144 patients with stage I or II follicular lymphoma treated between 1974 and 1988 with a median follow-up of 8.7 years (range, 48–182 months).
Staging procedures included bone marrow biopsy (98%), lymphangiography (87%), abdominal/pelvic CT (60%), and staging laparotomy (33%).
Patients received regional radiotherapy alone (n=45), combined chemotherapy and radiotherapy (n=84), or chemotherapy alone (n=15).
Actuarial survival rates across the entire cohort at 5, 10, and 15 years were 81%, 69%, and 63%, with corresponding freedom from relapse rates of 66%, 56%, and 46%.
Freedom from relapse at 15 years was higher with combined chemotherapy-radiotherapy compared to radiotherapy alone (63% vs. 35%), with no relapses observed after 7.5 years in the combined group versus ongoing relapses beyond 15 years with radiotherapy alone.
Univariate analysis identified patient age as the only significant prognostic factor, with no significant survival differences detected among the three histologic subtypes.

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Implication

Cohort study reveals improved freedom from relapse with combined chemoradiotherapy in early-stage follicular lymphoma, suggesting increased potential for long-term cure.

Cite This Study

Besa et al. (1995) studied this question.

synapsesocial.com/papers/6a16c62866334ab13b054d29 https://doi.org/10.1002/1097-0142(19950501)75:9<2361::aid-cncr2820750928>3.0.co;2-n

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Implication

Cohort study reveals improved freedom from relapse with combined chemoradiotherapy in early-stage follicular lymphoma, suggesting increased potential for long-term cure.

Long term assessment of patterns of treatment failure and survival in patients with stage I or II follicular lymphoma

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Discussion

Implication

Cite This Study

Long term assessment of patterns of treatment failure and survival in patients with stage I or II follicular lymphoma

Key Points

Discussion

Implication

Cite This Study

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