What question did this study set out to answer?

To determine the clinical significance and prognostic impact of histologic transformation over time in patients with nodular non-Hodgkin's lymphoma.

February 1, 1982BloodOpen Access

Histologic progression in non-Hodgkin's lymphoma

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To determine the clinical significance and prognostic impact of histologic transformation over time in patients with nodular non-Hodgkin's lymphoma.
Retrospective analysis of clinical courses and biopsy specimens from 515 consecutive patients with non-Hodgkin's lymphoma, focusing on 205 initially diagnosed with nodular lymphoma.
Evaluation of 63 patients who underwent a repeat biopsy more than 6 months after initial diagnosis to assess histologic changes categorized by Rappaport classification.
Histologic transformation to diffuse or aggressive subtypes occurred in 30% of rebiopsied patients (n=19/63), whereas 63% (n=40/63) retained a nodular pattern without cell type change.
Survival after repeat biopsy was significantly shorter in patients who underwent progression to diffuse histology than in those with persistent nodular histology (p < 0.001).
Achievement of complete remission with intensive combination chemotherapy conferred prolonged survival in eight patients and prolonged disease-free survival in one patient despite histologic progression.

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Implication

Retrospective study demonstrates reduced survival following histologic progression in nodular lymphoma, highlighting the prognostic value of repeat biopsies.

Cite This Study

Hubbard et al. (1982) studied this question.

synapsesocial.com/papers/6a16c666c23c548e2a7b8b44 https://doi.org/10.1182/blood.v59.2.258.258

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Implication

Retrospective study demonstrates reduced survival following histologic progression in nodular lymphoma, highlighting the prognostic value of repeat biopsies.

Histologic progression in non-Hodgkin's lymphoma

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Discussion

Implication

Cite This Study

Histologic progression in non-Hodgkin's lymphoma

Key Points

Discussion

Implication

Cite This Study

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