Key result
Iloprost indirectly suppressed endothelial tissue factor expression by inhibiting monocyte-derived cytokine amplification, abolishing TNF-alpha and reducing IL-1 beta secretion by 45%.
Population
Human umbilical vein endothelial cells and monocytic THP-1 cells
Comparison
Prostacyclin analogues vs Untreated cells or cells treated with LPS…
Design
Preclinical
Authors
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May reduce vascular thrombogenicity via cytokine pathways; extends monocyte data but leaves open clinical translation.
Prostacyclin analogues indirectly suppress endothelial tissue factor expression by inhibiting the amplification produced by monocyte-derived cytokines, rather than through direct endothelial effects.
Crutchley et al. (1993) studied Endothelial cell tissue factor expression. Prostacyclin analogues (Iloprost, carbacyclin, ciprostene) vs. Control was evaluated on Endothelial tissue factor expression and procoagulant activity. Iloprost indirectly suppressed endothelial tissue factor expression by inhibiting monocyte-derived cytokine amplification, abolishing TNF-alpha and reducing IL-1 beta secretion by 45%.
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