Key result
Fibrin formed on cultured human umbilical vein endothelial cells increased the synthesis of both prostacyclin and tissue plasminogen activator in a dose- and time-dependent manner.
Why the study?
Does fibrin formation on cultured human umbilical vein endothelial cells alter the synthesis of prostacyclin and t-PA?
Does fibrin formation on cultured human umbilical vein endothelial cells alter the synthesis of prostacyclin and t-PA?
Fibrin formation on endothelial cells stimulates the production of prostacyclin and t-PA, which may act in vivo to limit vascular occlusion by inhibiting platelet function and stimulating fibrinolysis.
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May limit thrombosis in vivo via endothelial prostacyclin and t-PA; leaves open in vivo relevance.
Kaplan et al. (1989) studied Endothelial cell function. Fibrin formation vs. Fibrin I, collagen polymerization, thrombin alone, soluble fibrin II was evaluated on Synthesis of prostacyclin and tissue plasminogen activator (t-PA). Fibrin formed on cultured human umbilical vein endothelial cells increased the synthesis of both prostacyclin and tissue plasminogen activator in a dose- and time-dependent manner.
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