Key result
Type 2 diabetes patients with coronary artery disease exhibited a significantly lower daytime decrease in PAI-1 compared to diabetic patients without CAD (4.4% vs 35.0%; P<0.05).
Population
60 subjects including 26 type 2 diabetic patients with coronary artery disease, 10 T2D patients without CAD…
Design
Cross-sectional
Authors
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May indicate heightened thrombotic risk in T2D with CAD; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=60)
Absolute Event Rate: 4.4% vs 35%
p-value: p=<0.05
Altered diurnal fluctuation of PAI-1 in T2D patients with CAD is strongly associated with hyperinsulinemia, insulin resistance, and abdominal obesity, which may contribute to accelerated atherosclerosis.
Lalić et al. (2015) conducted an observational in Type 2 diabetes and coronary artery disease (n=60). Type 2 diabetes patients with coronary artery disease exhibited a significantly lower daytime decrease in PAI-1 compared to diabetic patients without CAD (4.4% vs 35.0%; P<0.05).
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