What does this research mean for the field?

Sarcomere 'give' during the stretch of active muscle is caused by the forcible detachment of actin-myosin cross-bridges, which occurs at a filament displacement of 11-12 nm, representing the maximum attachment range of a cross-bridge. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1978The Journal of PhysiologyOpen Access

Sarcomere 'give' occurs when filaments are displaced by 11-12 nm from their steady-state position, coinciding with an abrupt elongation of the sarcomeres.

View Full Paper

Ask AI

Bookmark

Population

isometrically contracting frog muscle

Design

Preclinical

Authors

FFFrederick W. Flitney DHD G Hirst

Discussion

Member takes

Overview

Supports cross-bridge detachment as driver of sarcomere give in active stretch; extends muscle mechanics models but leaves translation to mammalian myocardium open.

Structured PICO

Population

isometrically contracting frog muscle

Intervention

servo-controlled stretches (ramp-and-hold stretch of approximately 1 mm)

Outcome

tension responses and sarcomere length changessurrogate

Sarcomere 'give' during stretch of active frog muscle is likely due to forcible detachment of cross-bridges between actin and myosin filaments at a displacement of 11-12 nm.

Cite This Study

Flitney et al. (1978) studied this question.

synapsesocial.com/papers/6a16d83ff3be5e880d6b9e11 https://doi.org/10.1113/jphysiol.1978.sp012246

View Full Paper

Ask AI

Bookmark

March 1, 1978The Journal of PhysiologyOpen Access

Sarcomere 'give' occurs when filaments are displaced by 11-12 nm from their steady-state position, coinciding with an abrupt elongation of the sarcomeres.

View Full Paper

Ask AI

Bookmark

Population

isometrically contracting frog muscle

Design

Preclinical

Authors

FFFrederick W. Flitney DHD G Hirst

Discussion

Member takes

Overview

Supports cross-bridge detachment as driver of sarcomere give in active stretch; extends muscle mechanics models but leaves translation to mammalian myocardium open.

Structured PICO

Population

isometrically contracting frog muscle

Intervention

servo-controlled stretches (ramp-and-hold stretch of approximately 1 mm)

Outcome

tension responses and sarcomere length changessurrogate

Sarcomere 'give' during stretch of active frog muscle is likely due to forcible detachment of cross-bridges between actin and myosin filaments at a displacement of 11-12 nm.

Cite This Study

Flitney et al. (1978) studied this question.

synapsesocial.com/papers/6a16d83ff3be5e880d6b9e11 https://doi.org/10.1113/jphysiol.1978.sp012246

View Full Paper

Ask AI

Bookmark