Key result
A uPCR cutoff of 0.09 g/gCr effectively predicts microalbuminuria in non-diabetic lifestyle-related diseases.
Why the study?
Early intervention is desirable to suppress kidney failure and cardiovascular disease from non-diabetic lifestyle-related diseases, prompting investigation into whether microalbuminuria could be predicted from proteinuria.
Can microalbuminuria be accurately predicted from the urinary protein-to-creatinine ratio (uPCR) in patients with non-diabetic lifestyle-related diseases?
Observational (n=303)
No
Can microalbuminuria be accurately predicted from the urinary protein-to-creatinine ratio (uPCR) in patients with non-diabetic lifestyle-related diseases?
Effect estimate: AUC 0.89
In Japanese patients with non-diabetic lifestyle-related diseases, microalbuminuria can be accurately predicted using a uPCR cut-off of 0.07 g/gCr for GFR stages G1-3a and 0.09 g/gCr for stages G3b-4.
No takes yet. Share an insight, caveat, or question.
May support uPCR screening in non-diabetic patients; leaves open prospective validation before practice change.
Ogi et al. (2021) conducted an observational in Chronic kidney disease due to non-diabetic lifestyle-related diseases and diabetes (n=303). Urinary protein-to-creatinine ratio (uPCR) was evaluated on Prediction of microalbuminuria using second uPCR in G1-4 non-diabetic patients (AUC 0.89). A urinary protein-to-creatinine ratio cut-off of 0.09 g/gCr effectively predicted microalbuminuria in patients with non-diabetic lifestyle-related diseases (AUC 0.89, sensitivity 0.76, specificity 0.89).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: