What question did this study set out to answer?

To determine how the cell cycle machinery regulates replication-dependent histone gene transcription upon entry into S phase.

September 15, 2000Genes & DevelopmentOpen Access

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

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Authors

JZJiyong ZhaoPLA Army Engineering University BKBrian K. KennedyNational University of Singapore BLBrandon D. LawrenceUniversity of Utah

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Implication

Molecular study reveals NPAT coordinates histone gene transcription via cyclin E-Cdk2 in human cells, indicating how cell cycle machinery regulates chromatin synthesis.

Key Points

To determine how the cell cycle machinery regulates replication-dependent histone gene transcription upon entry into S phase.
Assessed the association of NPAT and cyclin E with human replication-dependent histone gene clusters on chromosomes 1 and 6 during S phase.
Tested the effects of NPAT and the cyclin E–Cdk2 complex on histone gene promoter elements previously implicated in cell cycle-dependent transcription.
NPAT associated with replication-dependent histone gene loci on chromosomes 1 and 6 specifically in S phase.
NPAT activated histone gene transcription in a manner dependent on specialized promoter elements.
Cyclin E localized to histone gene loci and the cyclin E–Cdk2 complex enhanced NPAT-mediated transcription.

Cite This Study

Zhao et al. (2000) studied this question.

synapsesocial.com/papers/6a16e2c125571367076bb327 https://doi.org/10.1101/gad.827700

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Implication

Molecular study reveals NPAT coordinates histone gene transcription via cyclin E-Cdk2 in human cells, indicating how cell cycle machinery regulates chromatin synthesis.

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

Discussion

Member takes

Implication

Key Points

Cite This Study

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

Discussion

Member takes

Implication

Key Points

Cite This Study

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