Key result
Vancomycin infusion (1 g over 30-60 min) administered under anesthesia did not result in significant adverse hemodynamic consequences compared to saline.
Why the study?
Does vancomycin administration after anesthesia induction aggravate hypotensive effects compared to administration before induction in adults?
RCT (n=36)
Double-blind
Does vancomycin administration after anesthesia induction aggravate hypotensive effects compared to administration before induction in adults?
Vancomycin can be safely administered over 30-60 minutes during anesthesia without significantly aggravating hypotensive effects, contrary to manufacturer warnings.
No takes yet. Share an insight, caveat, or question.
May allow safe intraoperative vancomycin use; challenges manufacturer warnings against anesthetized administration.
Kaenel et al. (1993) conducted an RCT in Anesthesia (n=36). Vancomycin vs. Saline was evaluated on Heart rate and blood pressure. Vancomycin infusion (1 g over 30-60 min) administered under anesthesia did not result in significant adverse hemodynamic consequences compared to saline.
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