Key result
This review article summarizes the characteristics of the catechol O-methyltransferase (COMT) enzyme, its genetics, metabolism, and the properties and clinical possibilities of selective COMT inhibitors.
Provides a historical overview and review of the characteristics of COMT and its selective inhibitors.
No takes yet. Share an insight, caveat, or question.
Updates COMT biology and inhibitor prospects; extends prior reviews while leaving clinical translation open.
Männistö et al. (1992) conducted a review in Catechol O-methyltransferase (COMT) characteristics. COMT inhibitors was evaluated. This review article summarizes the characteristics of the catechol O-methyltransferase (COMT) enzyme, its genetics, metabolism, and the properties and clinical possibilities of selective COMT inhibitors.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: