What question did this study set out to answer?

To evaluate the efficacy and safety of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) against symptomatic virologically confirmed dengue in children living in endemic areas.

November 3, 2014New England Journal of MedicineOpen Access

Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

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Authors

LVLuis VillarColciencias GDGustavo H. DayanSanofi (United States)JAJosé Luis Arredondo-Garcı́aMexican Social Security Institute

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Implication

Randomized trial demonstrates that tetravalent dengue vaccination reduces virologically confirmed dengue in children, indicating substantial protection against severe disease and hospitalization.

Key Points

To evaluate the efficacy and safety of a recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) against symptomatic virologically confirmed dengue in children living in endemic areas.
Phase 3, randomized, double-blind, placebo-controlled trial (NCT01374516) conducted across five Latin American countries where dengue is endemic.
A total of 20,869 healthy children aged 9 to 16 years were randomly assigned in a 2:1 ratio to receive three injections of CYD-TDV or placebo at months 0, 6, and 12, followed for 25 months.
In the per-protocol population, 176 VCD cases occurred across 11,793 person-years in the vaccine group versus 221 cases across 5,809 person-years in the control group, demonstrating a vaccine efficacy of 60.8% (95% CI, 52.0 to 68.0), and 64.7% (95% CI, 58.7 to 69.8) in the intention-to-treat population.
Serotype-specific efficacy was 50.3% for serotype 1, 42.3% for serotype 2, 74.0% for serotype 3, and 77.7% for serotype 4, with 95.5% efficacy against severe dengue (1 of 12 cases in vaccinees) and 80.3% efficacy against hospitalization.

Cite This Study

Villar et al. (2014) studied this question.

synapsesocial.com/papers/6a16fa4566334ab13b058dff https://doi.org/10.1056/nejmoa1411037

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Implication

Randomized trial demonstrates that tetravalent dengue vaccination reduces virologically confirmed dengue in children, indicating substantial protection against severe disease and hospitalization.

Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

Discussion

Member takes

Implication

Key Points

Cite This Study

Efficacy of a Tetravalent Dengue Vaccine in Children in Latin America

Discussion

Member takes

Implication

Key Points

Cite This Study

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