Key result
Chronic cigarette smoke impairs vascular function in Apoe-/- mice by reducing aortic distensibility and elasticity.
Why the study?
Does chronic cigarette smoke exposure impair aortic structure and function in female Apoe-/- mice?
Does chronic cigarette smoke exposure impair aortic structure and function in female Apoe-/- mice?
Answers are grounded in this paper and cite their sources.
Chronic cigarette smoke exposure impairs aortic biomechanics and promotes a vulnerable atherosclerotic phenotype in a mouse model, providing mechanistic insight into smoking-related cardiovascular disease.
We studied the effects of chronic cigarette smoking on the structure and function of the aorta in a mouse model of nose-only aerosol inhalation. Our data indicated that exposure to cigarette smoke impairs vascular function by reducing the ability of the aorta to store elastic energy and by decreasing aortic distensibility. Combined with a more vulnerable atherosclerotic phenotype, these findings reveal the biomechanical mechanisms that support the development of cardiovascular disease due to cigarette smoking.
No takes yet. Share an insight, caveat, or question.
Farra et al. (2021) studied Cigarette smoke exposure. Chronic cigarette smoke exposure was evaluated on Structure and function of the aorta (elastic energy storage and aortic distensibility). Chronic cigarette smoke exposure impairs vascular function in female Apoe-/- mice by reducing aortic elastic energy storage and distensibility, promoting a vulnerable atherosclerotic phenotype.
Synapse has enriched 10 related papers. Consider them for comparative context: