June 1, 2014Open Access

Remodeling of rat pulmonary artery induced by chronic smoking exposure.

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Why the study?

Does chronic smoking exposure induce pulmonary artery remodeling in male Sprague-Dawley rats?

Population

70 male Sprague-Dawley (SD) rats

Comparison

Chronic smoking exposure vs Sham exposure during the same period

Design

Preclinical

Follow-up

Up to 5 months

Authors

LZLei ZhaoSichuan Agricultural University JWJian WangWenzhou Medical University LWLu WangWannan Medical College

Discussion

Member takes

Implication

Hypothesis-generating in a rat smoking model; leaves open human translation and clinical relevance.

Structured PICO

Does chronic smoking exposure induce pulmonary artery remodeling in male Sprague-Dawley rats?

Population

70 male Sprague-Dawley (SD) rats

Intervention

Chronic smoking exposure (36 cigarettes per day, 6 days per week, for 1, 3, or 5 months)

Comparator

Sham exposure during the same period

Outcome

Pulmonary artery remodeling assessed by hemodynamic measurement, right ventricular hypertrophy index (RVHI), right ventricle-to-weight ratio, and morphometric measurementssurrogate

Chronic smoking exposure induces pulmonary vascular remodeling and right ventricular hypertrophy in rats, potentially mediated by increased SOCE and TRPC1/4/6 via augmented BMP4 expression.

Cite This Study

Zhao et al. (2014) studied this question.

synapsesocial.com/papers/6a7cc89afecf32cfa0611b17 https://doi.org/10.3978/j.issn.2072-1439.2014.03.31

View Full Paper

Ask AI

Bookmark

Remodeling of rat pulmonary artery induced by chronic smoking exposure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Remodeling of rat pulmonary artery induced by chronic smoking exposure.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider