Key result
CPAP adherence in OSA and resistant hypertension is linked to ~1.6 lower BMI and reduced heart rate.
Why the study?
The study investigated whether long-term CPAP treatment in patients with OSA and resistant hypertension could attenuate cardiovascular disease risk by lowering body-mass index.
Does long-term CPAP therapy reduce BMI and improve cardiovascular outcomes in patients with obstructive sleep apnea and resistant hypertension?
Observational (n=33)
Does long-term CPAP therapy reduce BMI and improve cardiovascular outcomes in patients with obstructive sleep apnea and resistant hypertension?
Absolute Event Rate: -1.6% vs 1.4%
p-value: p=0.006
Long-term adherence to CPAP therapy in patients with OSA and resistant hypertension is associated with significant reductions in BMI and heart rate, and may prevent increases in arrhythmia prevalence.
May support CPAP adherence for BMI control in OSA with resistant hypertension; hypothesis-generating and requires RCTs before practice change.
Background: We sought to investigate whether long-term continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA) and resistant hypertension (RHTN) could attenuate the cardiovascular disease risk by lowering their body-mass index (BMI). Methods: This was a long-term observational study of RHTN patients diagnosed with OSA. Patients were evaluated with polysomnography initially and after a mean follow-up period of four years. The patients were divided into two groups based on their compliance to CPAP therapy. Results: 33 patients (aged 54.67 ± 7.5, 18 men, 54.5%) were included in the study, of which 12 were compliant to CPAP therapy. A significant reduction in BMI at follow-up was noted in patients compliant to CPAP therapy (1.4 ± 3.5 vs. −1.6 ± 2.5, p = 0.006). We also noted a large effect size reduction in abdominal circumference at follow-up in the CPAP group. At follow-up evaluation, the mean heart rate (b/min) was lower in the CPAP group (58.6 ± 9.5 vs. 67.8 ± 7.8), while arrhythmia prevalence increased between initial (28.6%) and follow-up (42.9%) evaluation with an intermediate effect size in non-compliant patients. Conclusions: In our cohort of OSA patients with RHTN, long-term adherence to CPAP therapy was associated with weight loss and improvement in cardiac rhythm outcomes.
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Pleavă et al. (2020) conducted an observational in Obstructive sleep apnea and resistant hypertension (n=33). Continuous positive airway pressure (CPAP) therapy (compliant) vs. Non-compliant to CPAP therapy was evaluated on Change in body-mass index (BMI) (p=0.006). Long-term adherence to CPAP therapy in patients with OSA and resistant hypertension was associated with a significant reduction in BMI (-1.6 vs 1.4, p=0.006) and lower mean heart rate.
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