February 1, 1999Journal of Applied Physiology
Effect of increasing central venous pressure during passive heating on skin blood flow
Key result
Rapid saline infusion (15 ml/kg) during passive heating restored central venous pressure and significantly increased cutaneous vascular conductance (P<0.05), unlike in normothermic controls.
Why the study?
Does increasing central venous pressure via saline infusion augment skin blood flow during passive heating in humans?
Structured PICO
Does increasing central venous pressure via saline infusion augment skin blood flow during passive heating in humans?
P
Population
7 human subjects
I
Intervention
Rapid intravenous infusion of 15 ml/kg warm saline during passive whole-body heating
C
Comparator
Rapid intravenous infusion of 15 ml/kg saline in normothermic subjects (volume control)
O
Outcome
Cutaneous vascular conductance and central venous pressuresurrogate
Main Result
p-value: p=<0.05
Cardiopulmonary baroreceptor unloading during passive heating attenuates the elevation in skin blood flow in humans.
Authors
Discussion
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Implication
Supports baroreflex unloading attenuating skin blood flow in heat stress; leaves open whether volume expansion alters thermoregulation clinically.
Cite This Study
Crandall et al. (1999) studied Healthy subjects (n=7). Intravenous warm saline infusion vs. Normothermic volume control was evaluated on Cutaneous vascular conductance and central venous pressure (p=<0.05). Rapid saline infusion (15 ml/kg) during passive heating restored central venous pressure and significantly increased cutaneous vascular conductance (P<0.05), unlike in normothermic controls.