What question did this study set out to answer?

To develop a multivariate random-effects model that combines survival proportions reported across multiple time points from different clinical trials in a meta-analysis.

May 9, 2008Statistics in Medicine

Meta‐analysis of summary survival curve data

View Full Paper

Ask AI

Bookmark

Authors

LALidia R. ArendsErasmus MC MHM. G. Myriam HuninkCardiac Imaging TSTheo StijnenGeneral Cardiology

Discussion

Member takes

Implication

Methodological study demonstrates a multivariate random-effects model for combining survival curve data across clinical trials, indicating improved synthesis of longitudinal survival outcomes.

Key Points

To develop a multivariate random-effects model that combines survival proportions reported across multiple time points from different clinical trials in a meta-analysis.
Formulated a multivariate random-effects framework generalizing Dear's fixed-effects model for joint analysis of multi-time-point summary survival proportions.
Evaluated the proposed methodology using a simulated data example and applied it to an aggregated clinical trial dataset of survival curve estimates.
Implemented model fitting using standard general linear mixed model software routines.
Demonstrated that the multivariate random-effects model successfully incorporates between-study heterogeneity and correlations across multiple survival time points.
Confirmed through simulated and clinical examples that standard linear mixed model software can reliably perform all required estimation and inference procedures without requiring custom algorithms.

Cite This Study

Arends et al. (2008) studied this question.

synapsesocial.com/papers/6a170feff3be5e880d6be691 https://doi.org/10.1002/sim.3311

View Full Paper

Ask AI

Bookmark

Implication

Methodological study demonstrates a multivariate random-effects model for combining survival curve data across clinical trials, indicating improved synthesis of longitudinal survival outcomes.

Meta‐analysis of summary survival curve data

Discussion

Member takes

Implication

Key Points

Cite This Study

Meta‐analysis of summary survival curve data

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider