Key result
Evening binge alcohol increases morning-after MSNA ~13% during Valsalva and reduces REM sleep.
Why the study?
Chronic binge alcohol consumption is linked to cardiovascular disease risk and disrupts morning sleep quality coinciding with the morning sympathetic surge, prompting investigation into morning sympathetic activity after evening binge drinking.
Does evening binge alcohol consumption increase morning-after muscle sympathetic nerve activity and disrupt sleep in young, healthy adults?
RCT (n=22)
Randomized crossover
No
Does evening binge alcohol consumption increase morning-after muscle sympathetic nerve activity and disrupt sleep in young, healthy adults?
Absolute Event Rate: 43% vs 38%
p-value: p=0.036
Evening binge alcohol increases next-day sympathetic reactivity and reduces REM sleep; extends sparse randomized data on acute effects in healthy adults.
Chronic binge alcohol consumption is associated with future cardiovascular disease (CVD) risk in both men and women. In addition, binge alcohol consumption is known to disrupt normal sleep quality during the early morning hours, coinciding with the morning sympathetic surge. In the present study, an evening of binge alcohol consumption increased baseline morning heart rate and cardiovascular reactivity during the Valsalva maneuver (VM) strain. Specifically, muscle sympathetic nerve activity and phase IV hemodynamic responses increased during VM the morning after binge alcohol consumption. The autonomic dysfunction and increased cardiovascular reactivity during VM suggests a contributing mechanism to CVD risk present in individuals who binge drink.
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Greenlund et al. (2020) conducted an RCT in Healthy adults with history of binge drinking (n=22). Evening binge alcohol consumption vs. Fluid control (fruit juice) was evaluated on Morning-after muscle sympathetic nerve activity (MSNA) burst frequency during Valsalva's maneuver (p=0.036). Evening binge alcohol consumption significantly increased morning-after muscle sympathetic nerve activity during Valsalva's maneuver and reduced REM sleep compared to fluid control.
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